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Crabescein is an innovative chemical product developed by PS Chemical Consortium. With a CAS number of 102072-98-0, Crabescein is recognized for its specialized role in biochemical research, particularly in studying protein dynamics. As a derivative of fluorescein, Crabescein exhibits unique properties that make it indispensable in advanced scientific applications, especially in understanding the behavior and interaction of immunoglobulins.
Crabescein has the molecular formula C₂₅H₂₂N₂O₅S₂ and a molecular weight of 494.6 g/mol. Its chemical structure, denoted by synonyms such as 4-(3-hydroxy-6-oxoxanthen-9-yl)-1-N,3-N-bis(2-sulfanyl ethyl)benzene-1,3-dicarboxamide, underscores its complexity and utility. The substance is identified as a fluorescein derivative, offering distinct advantages in labeling and tracking proteins, particularly immunoglobulin G (IgG). Crabescein binds covalently to the third disulfide bond in the hinge region of IgG, providing precise measurements of rotational correlation time, which is critical for understanding the dynamics of protein segments.
The production of Crabescein involves a sophisticated synthesis process. The process begins with the preparation of the core fluorescein structure, which is then modified to introduce the unique 1,3-benzenedicarboxamide moiety. This modification is crucial as it allows the compound to form two-point attachments to proteins, a feature that sets Crabescein apart from other fluorescent probes. The synthesis process is tightly controlled to ensure the high purity and consistency of Crabescein, making it a reliable tool for researchers. The final product undergoes rigorous testing to confirm its effectiveness in reporting protein dynamics, ensuring that it meets the stringent standards required for advanced biochemical research.
